Online CGH Tumor Database

Introduction

The Online CGH Tumor Database established in April 1999 provides information about part of the CGH tumor collectives investigated in our group.

The tumor collectives listed below can be explored in two different ways:

1. non-interactive database browsing (recommended if you are first-time user)
2. interactive database browsing

You can select your preferred method after clicking on a tumor collective. More information about the two methods.
Furthermore, the CGH tumor database can be searched for cases showing any desired pattern of chromosomal alteration.

Tumor collectives

Cervix carcinomas

• 12 primary tumors of cervix carcinomas (cases G01 to G12)
• 12 cell line tumors of cervix carcinomas (cases T01 to T12)

Lung carcinomas

Cell lines

• 23 lung cancer cell lines   (Supplemental Cell Line Data)

Small-cell lung cancer (SCLC)

Publication: Petersen et al., British Journal of Cancer (1997), 75(1), 79-86

• 24 cases of small-cell lung cancer

Squamous cell carcinomas (SCCs)

Publication: Petersen et al., British Journal of Cancer (2000), 82(1), 65-73

• 25 primary squamous cell carcinomas of the lung (pN0/pM0)
• 25 metastasizing squamous cell carcinomas of the lung
• 50 squamous cell carcinomas of the lung (union of primary and metastasizing collectives)

Comparison between primaries and metastases

• Case L23, primary tumor (PT) and 1 metastasis
• Case L27, PT and 2 metastases
• Case L31, PT and 1 metastasis
• Case L34, PT and 2 metastases
• Case L37, PT and 1 metastasis
• Case L39, PT and 2 metastases
• Case L40, PT and 3 metastases
• Case L171, PT and 1 metastasis
• Case L219, PT and 1 metastasis
• Case L220, PT and 1 metastasis

Combined carcinomas

• Squamous cell carcinoma and small-cell lung cancer

Adenocarcinomas

Journal of Pathology (2001)  (Patient data)

Publication: Goeze et al., Journal of Pathology (2001), accepted for publication

• 59 primary tumors of adenocarcinomas of the lung
• 22 non-metastasizing adenocarcinomas of the lung
• 35 metastasizing adenocarcinomas of the lung

Comparison between primaries and metastases

• Case L81, primary tumor (a) and 2 metastases
• Case L114, primary tumor (a) and 4 metastases
• Case L107, primary tumor (a) and 2 metastases
• Case L115, primary tumor (a) and 4 metastases
• Case L109, primary tumor (a) and 3 metastases
• Case L110, primary tumor (a) and 2 metastases
• Case L113, primary tumor (a) and 2 metastases
• Case L95, primary tumor (a) and 1 metastasis
• Case L97, primary tumor (a) and 1 metastasis
• Case L105, primary tumor (a) and 3 metastases

Primary adenocarcinoma (L319) and two intrapulmonary metastases (CGH profiles and histological images)

• Case L319, PT and 2 intrapulmonary metastases

Mamma carcinomas

Cell lines

• Breast cancer cell lines from ATCC   (Supplemental Cell Line Data)

Ductal and lobular breast carcinomas and sub collectives

Publication: Richard et al., Int J Cancer {Pred Oncol} (2000), 89(3), 305-310

Ductal and lobular breast carcinomas

• 80 invasive ductal breast carcinomas
• 25 invasive lobular breast carcinomas

Sub collectives from union of ductal and lobular breast carcinoma collectives

• 81 estrogen receptor positive cases
• 22 estrogen receptor negative cases
• 30 well differentiated cases
• 35 poorly differentiated cases
• 20 cases from patients with age < 50
• 85 cases from patients with age >= 50
• 50 non-metastasizing cases (pN0)
• 37 metastasizing cases (pN1/2)
• 59 cases with tumor size pT1
• 46 cases with tumor size pT2-4

Head and neck carcinomas

Squamous cell carcinomas (HNSCCs)

Comparison between metastasising and non-metastasising tumors

Publication: Bockmuhl et al., Cancer Research (1997), 57, 5213-5216

• 19 non-metastasizing HNSCCs (pN0)
• 29 metastasizing HNSCCs (pN1)

Chromosomal alterations correlated with survival

Publication: Bockmuhl et al., Am J Pathol (2000), 157(2), 369-375

• 113 primary tumors (all cases)

Comparison of primary tumors and their corresponding lymph node metastases

Publication: Bockmuhl et al., Genes Chromosomes Cancer (2002), 33,29-35

• 34 metastasizing primary tumors
• 38 corresponding lymph node metastases
• 20 non-metastasizing primary tumors

Esthesioneuroblastomas  (Doctoral thesis by You)

Publication: Bockmuhl et al., Brain Pathology (2004), 14, 158-163

• 22 esthesioneuroblastomas (all)
• 12 esthesioneuroblastoma primaries
• 8 esthesioneuroblastoma metastases
• 2 esthesioneuroblastoma recurrences

Comparison between primaries and metastases or recurrencies

• Case 3, primary tumor (a), 1 recurrency (b) and 1 metastasis (c)
• Case 5, primary tumor (a) and 4 metastases (c-f)
• Case 7, primary tumor (a) and 1 recurrency (b)
• Case 9, primary tumor (a) and 3 metastases (c-e)

Brain tumors

Metastases of different primaries

Publication: Petersen et al., Brain Pathology (2000), 10, 395-401

• 40 metastases (all)
• 14 lung metastases
• 7 melanoma metastases
• 5 breast metastases
• 5 colon metastases
• 4 kidney metastases
• 3 metastases of unknown primaries
• 1 adrenal gland metastasis
• 1 thyroid carcinoma metastasis

Pilocytic astrocytomas

Publication: Neurosurg Focus (2000) 8(4): Clinical Pearl 2

• 18 pilocytic astrocytomas (all cases)   (Article Online)
• pilocytic astrocytomas - first group with pronounced gains
• pilocytic astrocytomas - second group with multiple losses

Cellines

• 8 medullo blastomas cell lines

Colorectal carcinomas

Advanced colorectal carcinomas  (Patient data)

Publication: Knosel et al., Virchows Arch (2002), 440, 2, 187-194

• 54 primary tumors and metastases
• 24 primary tumors
• 30 metastases

Alterations during lymphatic and liver metastasis formation

Publication: Knosel et al., Neoplasia (2004), 6, 1, 23-28

• 63 primary tumors and metastases

Chromosomal alterations in lung metastases of colorectal carcinomas: associations with tissue specific tumor dissemination

• 85 primary tumors and metastases

Ovarian tumors

Adenomas

• 9 ovarian adenomas

LMP tumors

• 11 LMP tumors

Carcinomas

Non-serous carcinomas

• 13 non-serous carcinomas

Serous carcinomas

• 6 low serous carcinomas
• 8 high serous carcinomas
• Both 6 low and 8 high serous carcinomas

Cell lines

• 4 Cell lines